February 28th 2021 – Rare Disease Day, the commemorative day takes place on the last day of february of each year. This day was set to create awareness among the society and to provide information about the impact of Rare Disease in their lives. According to the EURORDIS it is important to create awareness since only 1 of every 20 people suffer from a Rare Disease.There are around 6,000 of Rare diseases that currently affect 3.5% – 5.9% of the worldwide population, the majority of these diseases appear due to a genetic problem. Here is a list to name a few:

Stiff-man Syndrome: is a rare, progressive syndrome that affects the nervous system, specifically the brain and spinal cord. Symptoms may include extreme muscle stiffness, rigidity and painful spasms in the trunk and limbs, severely impairing mobility. Spasms can generate enough force to fracture bone. People with SPS often have heightened sensitivity to noise, sudden movements, and emotional distress, which can set off muscle spasms. Persistent symptoms can lead to abnormal posturing of the spine, such as being hunched over.
Acute Febrile Neutrophilic Dermatosis: also known as Sweet Syndrome,is a very rare inflammatory skin condition characterized by a sudden onset of fever and painful rash on the arms, legs, trunk, face, or neck. It is suspected that it can be a reaction of the body to certain exposures like to the sun, infections involving Streptococcus bacteria and Campylobacter, or medications such as azathioprine, nonsteroidal anti-inflammatory medications. This condition can also occur with some types of cancer and other serious health problems.
Cervical dystonia is a neurological condition characterized by excessive pulling of the muscles of the neck and shoulder resulting in abnormal movements of the head (dystonia). Most commonly, the head turns to one side or the other. Tilting sideways, or to the back or front may also occur.
Sjögren’s Syndrome: is an autoimmune condition in which cells attack the glands that produce saliva and tears and other glands, especially those in the digestive tract. The syndrome also presents as a rheumatic disease in that it causes pain and swelling in the joints. Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain.
Retinitis Pigmentosa: is a group of inherited eye diseases that affect the light-sensitive part of the eye (retina). Retinitis Pigmentosa causes cells in the retina to die, causing progressive vision loss. The first sign of Retinitis Pigmentosa usually is night blindness. As the condition progresses, affected individuals develop tunnel vision (loss of peripheral vision), and eventually loss of central vision. Retinitis Pigmentosa may be caused by mutations in any of at least 50 genes.

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